List of Tissue Engineering Companies in Minnesota - 4

Tissx sources, manufactures and supplies tissue products and services for cardiac, vascular and other specialty surgeries. Our goal is to make affordable high quality tissue products available worldwide. We develop and manufacture products including fixed pericardial tissue patches and valve repair products. Tissx also works with corporations to source and supply tissue, provide OEM services and develop tissue bioprosthetics.

What we know: - Currently, 106,000 people in the U.S. are on the waitlist for a life-saving organ transplant. - 60% of patients on the waitlist will not receive the organ they need. - 17 people in the U.S. die each day due to the lack of available organs. What we're doing: Miromatrix Medical was founded with the mission to eliminate the transplant waitlist. Headquartered in Eden Prairie, Minnesota, we bioengineer organs through our patented perfusion decellularization and recellularization technology. We take what nature designed -- a fully functioning liver or kidney -- and with our patented technology, remove all of the cells from discarded pig organs. What's left is a ‘scaffold'; all of the organ's natural design and architecture remains. Then, from the inside out, we seed new, living human cells back into the organ -- ultimately creating completely functional, transplantable organs with the potential to save thousands of lives every year.

Ponte Biosciences, Inc. is a preclinical biotherapeutic company focused on developing a cell-based bioartificial liver system to treat acute forms of liver failure. The Company's Spheroid Reservoir Bioartificial Liver (SRBAL) system was developed at the Mayo Clinic and utilizes metabolically active primary hepatocytes (liver cells) to replace and/or supplement liver function for patients with liver failure being treated in the Intensive Care Unit (ICU).

Vascudyne Inc is a biotechnology company based in Minnesota, focused on regenerative medicine through engineered biological tissues. Founded in 2014 and headquartered in Stillwater, with operations in Saint Paul, Vascudyne develops acellular in-vitro grown allograft tissues that mimic the properties of natural human tissue. The company’s TRUE™ Tissue Technology is a proprietary platform that produces 100% biological soft tissue implants. Their product portfolio includes the TRUE™ Graft for vascular access in hemodialysis, the TRUE™ Valve for engineered valved conduits, and the TRUE™ Patch for tissue repair. Vascudyne emphasizes the use of biologically derived extracellular matrix materials and tunable anisotropic tensile properties in their manufacturing processes. Vascudyne has achieved significant milestones, including successful First-in-Human studies for the TRUE™ Graft and preclinical validations for their products. The company operates within Minnesota’s "Medical Alley," benefiting from the region's medtech ecosystem, and has raised a total of $19.63 million in funding to support its innovative work in regenerative biomaterials.