List of Microbiome Companies with Phase 4 Active Clinical Trial - 17

Adamas Biotech is a clinical stage company pioneering the development of nutraceutical-based prophylactic and therapeutic solutions for a range of clinical and wellness indications. The company is specialized in the development of bioactive molecules derived from botanicals, in particular, green tea catechins. Its initial pipeline is based on 100% natural formulations of green tea purified compounds, which are under development for use in cancer prevention, anti-aging, wound care and sports medicine.

BIO-CAT provides the very latest enzyme technology and custom formulations. Founded in 1988, our extensive range of products, from single-to-multi-enzyme blends, service various industrial, food, agriculture and other commercial markets. BIO-CAT is an FSSC 22000 certified facility in Virginia featuring state-of-the-art laboratories for scientific research, product development and on-site quality testing to better serve customers. BIO-CAT Microbials is an innovator in the field of biological solutions for a broad range of emerging and existing markets and industries. BIO-CAT Microbials is a GMP certified facility and a division of BIO-CAT, utilizing the latest enzyme technology in combination with microbes to produce products that are pioneering, more effective and of the highest quality for our customers’ applications.

BIOHM optimizes digestive health by combining good bacteria, good fungi and enzymes to break down digestive plaque, allowing for total gut balance. This allows BIOHM's 30 billion live active cultures to maintain, support, and promote the balance of the total microbiome in the digestive system.

Carbiotix is an award-winning biotechnology company pioneering the onsite upcycling of plant-based side-streams. Carbiotix mission is to improve the health of people by increasing the consumption of prebiotics and other active ingredients from upcycled side-streams. Carbiotix offers one core service today called NutraCycle, an on-site upcycling and fortification service allowing food & beverage, ingredient, and feed producers to turn plant-based products into healthier, more profitable, and sustainable products.

Freya™ is a clinical-stage company taking an innovative approach to women’s health, with microbial immunotherapies aimed at relieving the chronic inflammation underlying a range of reproductive system diseases uniquely afflicting women.

Merck & Co., Inc. operates as a healthcare company worldwide. It operates through two segments, Pharmaceutical and Animal Health. The Pharmaceutical segment offers human health pharmaceutical products in the areas of oncology, hospital acute care, immunology, neuroscience, virology, cardiovascular, and diabetes, as well as vaccine products, such as preventive pediatric, adolescent, and adult vaccines. The Animal Health segment discovers, develops, manufactures, and markets veterinary pharmaceuticals, vaccines, and health management solutions and services, as well as digitally connected identification, traceability, and monitoring products. It serves drug wholesalers and retailers, hospitals, and government agencies; managed health care providers, such as health maintenance organizations, pharmacy benefit managers, and other institutions; and physicians and physician distributors, veterinarians, and animal producers. The company has collaborations with AstraZeneca PLC; Bayer AG; Eisai Co., Ltd.; Ridgeback Biotherapeutics; and Gilead Sciences, Inc. to jointly develop and commercialize long-acting treatments in HIV. Merck & Co., Inc. was founded in 1891 and is headquartered in Kenilworth, New Jersey.

Founded in 1895, Nexira is a family owned company who built its reputation as the world leader in acacia gum. Today Nexira is a global leader in natural ingredients and botanical extracts for food, nutrition, and dietary supplements. Our ingredients are perfectly suitable for the formulation of clean label products. Nexira manufactures in France a wide range of natural ingredients with recognized health benefits, such as Fibregum™ an all-natural, organic and GMO-free source of soluble dietary fiber. Nexira's portfolio for food industry includes a large range of branded natural acacia gum ingredients with exceptional functional properties (Emulsifiers & stabilizers, coating agents, texturizers, encapsulating agents…). Nexira's portfolio for supplement industry includes premium nutraceuticals, strongly supported with scientific & marketing supports, for digestive health, weight management, sports nutrition, joint health and men & women’s health.

Persephone is pioneering the use of synthetic biology for microbial products that impact patient and infant health. We are building an end-to-end platform to industrialize the development of engineered cells that restore health to damaged human ecosystems. The company was founded in the summer of 2017 by synthetic and metabolic engineering pioneers, Stephanie Culler PhD, and Steve Van Dien PhD.

Probi® is a global company focused exclusively on researching, manufacturing, and delivering probiotics for supplements and functional food. We are experts at managing stable, live bacteria from R&D through every stage of the manufacturing process, and are dedicated to making the health-enhancing benefits of probiotics available to people everywhere. Our health concepts, formulations, and formats are supported by robust clinical documentation. Since our founding in 1991 at Sweden's Lund University, Probi has expanded its operations to more than 40 markets. We hold more than 400 patents globally.

Probiotical is an Italian family-owned company specialized since 1985 in probiotics manufacture, from the raw material to the finished products, with very high quality, guaranteed stability and scientifically backed strains. We are driving innovation in a variety of functionalities and technologies. We offer our customers wide opportunities of customization and range extensions for probiotic blends and finished products ready-to-market, either under Probiotical's brand or in private label.

science backed probiotics, prebiotics & bioactive botanicals for targeted restoration res makes physician developed & physician recommended supplements creator of the world's first respiratory probiotic resB!

Solarea Bio is a clinical-stage biotechnology company in Cambridge, MA developing plant-based microbial solutions to some of the world's largest health problems. Solarea was founded in 2017 by a group of scientists and entrepreneurs eager to radically alter our understanding of the human microbiome and utilize its power to improve human health. The Solarea breakthrough came from the combined efforts of the company's co-founders who established a link between the discovery of an untapped source of microorganisms with probiotic potential in healthy foods, and their applications in inflammatory processes including the gut-musculoskeletal axis. Using powerful genomic and bioinformatic tools, Solarea is mining its novel microbial strain collection to identify synergistic combinations of microbes and prebiotic plant fibers to develop solutions for patients suffering from inflammatory processes.

We strive to transform lives. While the science we advance is constantly evolving, our core purpose is enduring. For more than two centuries, our values have guided us to do what’s right for patients and for society. We know that changing lives requires us to do things differently. We start by listening to and addressing what really matters to patients, the people who love them, and those in the healthcare system who provide care. And that’s what inspires us all to be bold, push boundaries and set new standards that open up greater opportunities. Read our community guidelines: https://takeda.info/communityguidelines

From discovery to scale, Verb Biotics applies science, technology, and intentional development to deliver microbiome health solutions. Verb Biotics is a business-to-business ingredient supplier of pro, post, and synbiotics for food, beverage, and dietary supplement brands.

Viomeanalyzes your microbiome and uses artificial intelligence to process the results and provide dietary advice.

Winclove Probiotics, quality of life with probiotics Since 1987, Winclove Probiotics has specialized in the development and production of probiotics. We work with passionate business partners, leading universities, various research institutes and university hospitals around the world to develop effective indication-specific probiotics. Aiming for long-lasting, sustainable and strategic partnerships, we not only offer innovative, high-quality and competitive probiotic solutions but also share our scientific knowledge as much as possible. At Winclove Probiotics, commitment, drive and optimism are important. Our Great Place to Work certification also shows that we have a company culture of humanity, diversity and trust. Since 2020, we have been part of the B Corp community, joining forces with like-minded companies to protect our planet and contribute to a sustainable economy. Together, we are using ‘business as a force for good'. -- Winclove Probiotics, kwaliteit van leven met probiotica Sinds 1987 is Winclove Probiotics gespecialiseerd in de ontwikkeling en productie van probiotica. Wij werken met gedreven businesspartners, vooraanstaande universiteiten, uiteenlopende onderzoeksinstituten en (universitaire) ziekenhuizen wereldwijd om effectieve indicatiespecifieke probiotica te ontwikkelen. We streven naar langdurige, duurzame en strategische partnerships waarbij wij niet uitsluitend innovatieve, hoogwaardige en concurrerende probiotica-oplossingen bieden, maar ook zoveel mogelijk onze wetenschappelijke kennis delen. Bij Winclove Probiotics zijn betrokkenheid, gedrevenheid en optimisme belangrijk. Ons Great Place to Work-certificaat toont tevens aan dat we een bedrijfscultuur van menselijkheid, diversiteit en vertrouwen hebben. Sinds 2020 zijn we onderdeel van de B Corp-community en bundelen we met gelijkgestemde bedrijven de krachten om onze planeet te beschermen en bij te dragen aan een duurzame economie. Samen gebruiken we ‘business as a force for good.'

Yakult is the world's leading probiotic beverage created in Japan in 1935. It is produced by Yakult Honsha Co., Ltd - the world's pioneer in probiotics. Today, Yakult is sold in more than 30 countries and regions around the world. Our company's portfolio includes a range of consumer, cosmetic and pharmaceutical products. For additional company information, please visit www.yakult.co.jp/english/. Science and research are the basis of our business. We have institutes in both Japan and Europe that are committed to discovering the endless applications for probiotics as well as the use of intestinal bacteria in human health globally. For more information about our science institutes, please visit www.yakult.co.jp/institute. Bringing Yakult to America is just one more step towards fulfilling Yakult's mission: to contribute to the health and happiness of every person around the world through the pursuit of excellence in life sciences and the study of microorganisms. We hope to achieve this goal while providing education to people about healthier living, developing community programs where we do business, and collaborating with medical doctors, dietitians and researchers. Yakult U.S.A. Inc. is a subsidiary of Yakult Honsha Co., Ltd. and is headquartered in Fountain Valley, CA. It supports Yakult's business in the United States and Canada. To contact our offices please email yakult@yakultusa.com.